Endocrine Abstracts

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrinopathy characterized by tumours of the parathyroid glands, adenohypophyseal and pancreatic tumours. We present a case of a young, 24 years old female patient with a positive familial background for MEN1 (on the fathers’ side of the family). She is one of two sisters with determined heterozigocity of the MEN 1 gene (Exon 2, codon 111). At the age of 12, insulinoma of the head of the pancreas was diagnos...

Introduction: Hypercalcaemia in acromegaly can be a result of several pathophysiological mechanisms. Multiple endocrine neoplasia type 1 (MEN1) syndrome, mitogenic effect of hyperactivated GH–parathyroid gland axis, i.e. primary hyperparathyroidism and hypercalcaemia mediated by elevated 1,25-dihydroxyvitamin D should be considered.Case report: We describe a case of acromegaly associated with primary hyperparathyroidism. A 52-year-old female was dia...

Introduction: Thyroid hormone deficiency can lead to the impairment of cardiac function. Whether subclinical hypothyroidism (ScH) is a risk factor for left ventricular (LV) dysfunction is controversial. Aim of the study was to assess whether ScH is associated with LV systolic and diastolic dysfunction and it’s reversibility after treatment with L-thyroxine.Material and methods: Twenty-seven consecutive patients with newly diagnosed Sc...

Introduction: Hyponatremia is rarely reported as a delayed complication of transsphenoidal resection of pituitary adenoma. Severe hyponatraemia can cause potentially fatal conse-quences.Material and methods: A 34 year old patient was admitted as an urgent case at the Clinic of Endocrinology, with symptoms and signs of Addisonian crisis (dizziness, headaches, nausea, vomiting, hypotension), with muscular weakness and muscle aches, tingling hands and confu...

Introduction: Ectopic Cushing’s syndrome caused by ectopic ACTH secretion are under-diagnosed.Case report: A 50 years old male patient is hospitalized for severe hypokalaemia and diabetes. Last 6 months he had a history of chest pain, prolonged cough, general weakness, difficulties climbing stairs, confusion, loss of consciousness. Previously, he was hospitalized in psychiatric hospital for psychotic alterations, in cardiology for high blood pressur...

McCune–Albright syndrome (MAS) is characterized by fibrous dysplasia (FD), cutaneous cafe-au-lait pigmentation and autonomous hyper-secretory endocrinopathies. Association of acromegaly with MAS is very rare. We present a case of a 35-year-old men with MAS, diagnosed with poly-ostotic fibrous dysplasia at the age of 12, no history of premature puberty, with GH secreting cystic macroadenoma 40×35×45 mm big and clinical picture of acromegaly, hypopituitarism and b...

Objective: Surgery is considered first-line treatment for pituitary GH secreting macroadenoma. Since surgical removal of the pituitary tumor is subtotal, medical treatment has become the mainstay of acromegaly. The aim of our study was to assess the effect of octreotide LAR (OCT-LAR) therapy in patients with acromegaly.Patients and methods: Ten acromegalic patients were treated with OCT-LAR 20 mg/28 days. The effect was evaluated after 12 months of treat...

Introduction: The isolated hyperparathyroidism (IHP) is a metabolism disorder characterized by an absent or low parathormon (PTH) and hypocalcemia. It can be acquired, autoimmune, a result of some syndrome and as a part of a family (FIHP). FIHP is an extremely rear disease which is inherited auto somatic dominant or auto somatic recessive as a result of a mutation of one or several different genes. Pathological calcifications in the cerebrum are a secondary form of calcificati...

Introduction: Overt hypothyroidism and severe subclinical hypothyroidism (ScH) are associated with dyslipidaemia, and its condition is reversible after thyroid replacement therapy. We investigated the effect of levothyroxine therapy on lipid parameters in patients with mild form of subclinical hypothyroidism (ScH).Material and methods: Fifty-seven patients with newly diagnosed ScH with TSH levels below 10 mU/l and 30 age and sex-matched healthy subjects ...

Subclinical hyperthyroidism (ScHyper) is a condition with suppressed TSH, and normal free T3 and free T4 hormones, affecting 10% of the population. There are two subgroups of patients, the first group with TSH lower than 0.1 U/l, and the second group with mildly suppressed TSH between 0.1 and the lower assay reference limit. The patients from the first group should be treated, but there is no evidence for therapy for the second group of patients.We prese...